Histological features of autoimmune hepatitis: a critical appraisal

We speculate that the 'typical' histological features (lymphoplasmacytic interface hepatitis, emperipolesis and hepatocyte rosettes) of autoimmune hepatitis (AIH) are related to severity of hepatitis rather than etiology. We critically appraised various histologic features of AIH and compared them to cases of chronic hepatitis with similar inflammatory grade and fibrosis stage. Fifty one patients with clinically confirmed AIH were identified at our institution, of which 43 biopsies (from 42 patients) were taken prior to initiation of therapy and formed the study group.

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