Diffusion of Ca2+ from small boutons en passant into the axon shapes AP-evoked Ca2+ transients

Not only the amplitude but also the time course of a presynaptic transient determines multiple aspects of synaptic transmission. In small bouton-type synapses, the mechanisms underlying the decay kinetics have not been fully investigated. Here, factors that shape an action potential (AP)-evoked transient were quantitatively studied in synaptic boutons of neocortical layer 5 pyramidal neurons. transients were measured with different concentrations of fluorescent indicators and analysed based on a single-compartment model.

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