Cancers, Vol. 10, Pages 247: The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Cancers, Vol. 10, Pages 247: The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Cancers doi: 10.3390/cancers10080247

Authors: Sharmila Velapasamy Christopher W. Dawson Lawrence S. Young Ian C. Paterson Lee Fah Yap

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

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