Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice

Objective. To explore the association between the acquisition process in the Y-maze and H-2 class II polymorphisms in mice. Methods. Mice were trained for 5 consecutive days in the Y-maze. The value of the slope of the latent period was considered an indication for the acquisition process. A slope 0 indicated no learning. The H-2 polymorphism was determined with PCR amplification, and the correlation between the alleles and the acquisition process was analyzed. Results. The overall percentage of mice that learned was 46.1%. The percentage of mice that had learned with MudoEb5 (37.9%) was significantly lower than that of mice without MudoEb5 (61.1%; P

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