Tumor shrinkage during chemoradiation in locally advanced cervical cancer patients: prognostic significance, and impact for image-guided adaptive brachytherapy

The prognostic value of GTV and its evolution after chemoradiotherapy, assessed in 247 patients were examined first on initial staging MRI and then at time of brachytherapy. In multivariate analysis, GTV optimal volume reduction was independently associated with improved overall survival and local control (p<0.001). Patients with optimal GTV reduction had no significant benefit from dose escalation D90 CTVHR ≥80Gy (p>0.3) while patients without optimal GTV reduction may have (p<0.05).

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