Poor Prognostic Impact of FGF4 Amplification in Patients with Esophageal Squamous Cell Carcinoma

In the present study, we aimed to determine the prognostic impact and clinicopathological feature of FGF4 amplification in patients with esophageal squamous cell carcinoma (ESCC). Fluorescence in situ hybridization (FISH) with FGF4 probe was analyzed using tissue microarray consisting of representative cores of 267 ESCC cases. FGF4 amplification was observed in 52.8% (141/267) of patients. Patients with FGF4 amplification showed a significantly shorter disease free survival (DFS) or disease-specific overall survival (OS) compared with those without FGF4 amplification (both P<0.05).

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