Modeling patient-specific dose-function response using perfusion SPECT/CT for enhanced characterization of personalized functional changes

By quantifying the heterogeneous distribution of lung function prior to treatment, personalized radiotherapies have the potential to limit functional damage and reduce toxicity. However, a limited understanding of the normal tissue response to radiation has hindered the incorporation of functional information in treatment planning. This study applied a patient-specific modeling approach to enhance the characterization of the dose-function response in NSCLC patients treated with conventionally-fractionated RT and SBRT.

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