Is more always better in Barrett’s esophagus?

Patients diagnosed with Barrett' esophagus (BE) often face a challenging conundrum. They are informed that they have a premalignant condition with a risk of neoplastic progression that is proportional to the grade of dysplasia present on esophageal biopsies and that their condition will either be monitored through a surveillance program or treated, depending on this risk. Endoscopic surveillance follows the Seattle protocol, which consists of a detailed examination of the BE segment under high-definition white light endoscopy with targeted biopsies or resection of areas of mucosal irregularities followed by systematic 4-quadrant biopsies at set intervals along the entire length of the BE segment.

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