In Reply to Roos et al

To the Editor: We thank Roos et al for their interest in and comments on our article regarding combined hyperthermia (HT) and radiation therapy (RT) for patients with painful bone metastases (1, 2). We acknowledge that the analysis was limited by small patient population size. However, an individual centralized randomization process corresponding at the starting point to time of progression was standardized. The preset interim analysis time and rule of early termination by data safety monitoring committee were followed according to protocol and were regularly monitored by institution and health regulatory authorities for clinical testing.

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