C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Post-operative Residual Disease and Response to Chemoradiation Therapy

C11 Methionine PET may be a useful tool for delineation of radiation targets and assessment of response in glioblastoma. C11 Methionine PET scanning can show a significant decrease in extent of MET-avid glioblastoma at 1 month after completion of chemoradiation compared to the immediate post-operative period, even when T2/FLAIR changes little. MGMT promoter methylation status further predicts differential metabolic responses.

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