Use of Radiation in Extramedullary Leukemia/Chloroma: Guidelines from the International Lymphoma Radiation Oncology Group

Survival times for patients with leukemia in general have improved in recent decades, and this improvement has been attributed to an enhanced understanding of the genetics driving the etiology of the disease and improved combination chemotherapy and targeted therapy. Durable control of systemic disease in blood and bone marrow has significantly improved survival, but extramedullary relapse can pose therapeutic challenges for which radiation therapy can have an important role. The objective of this document is to discuss the current role of radiation therapy for patients with leukemia, specifically the extramedullary manifestations of leukemia.

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