The diagnostic role of BAP1 in serous effusions

The aim of this study was to analyze the diagnostic role of BAP1 in effusion cytology. Effusions (n=258), consisting of 53 malignant mesotheliomas and 205 other cancers, the majority carcinomas (62 breast, 60 ovarian, 31 lung, 51 carcinomas of other origin, 1 melanoma), were analyzed for BAP1 expression using immunohistochemistry. BAP1 was lost in 46 (87%) mesotheliomas, compared to 4/205 (2%) loss in other cancers (P<.001), resulting in sensitivity and specificity of 87% and 98%, respectively. There was no significant difference between peritoneal (n=14) and pleural (n=39) mesotheliomas.

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