In Patients With Acute Myocardial Infarction and No Hypoxemia, Does Oxygen Therapy Improve Outcomes Compared With No Supplemental Oxygen?

Authors included 7 randomized controlled trials with 3,842 patients receiving oxygen therapy and 3,860 patients not receiving supplemental oxygen. Time frames for outcome measurements ranged from index admission up to 12 months. Most included patients were men, and the most common comorbidities were hypertension, hyperlipidemia, diabetes, and smoking. Overall, there was no association between oxygen supplementation with any benefit in patients with acute myocardial infarction (Table). Six studies reported all-cause mortality, 6 reported recurrent ischemia or myocardial infarction, 3 reported heart failure, and 5 reported arrhythmia.

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