A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis

Kang and colleagues identify linc1405 as a crucial regulator of cardiac differentiation via its interaction with Eomes. Linc1405 mediates an Eomes/WDR5/GCN5 regulatory complex at the Mesp1 enhancer, which coordinates Mesp1 expression and cardiac specification. They also show that linc1405 depletion results in impaired heart development and function in vivo.

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