Pharmacokinetics of daptomycin in critically ill pediatric patients [PublishAheadOfPrint]

Daptomycin pharmacokinetics (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8-14 yrs. Area under the curve (AUC_0-) of plasma concentrations on day 1 ranged between 123.8-663.9 μg ⋅ h/ml, with lower values observed in septic and burn patients; clearance ranged between 15.1-80.7 ml/h/kg. Higher than recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Inter-patient variability may suggest a role for therapeutic drug monitoring.

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