Mucinous Histology Signifies Poor Oncologic Outcome in Young Patients With Colorectal Cancer

BACKGROUND: The incidence of colorectal cancer in the young (under age 40) is increasing, and this population has worse oncologic outcomes. Mucinous histology is a potential prognostic factor in colorectal cancer, but has not been evaluated specifically in young patients. OBJECTIVE: The objective of the study was to determine factors associated with poor outcome in young patients with colorectal cancer (≤40 years) and to determine relationships between mucinous histology and oncologic outcomes in this population. DESIGN: This is a retrospective study. SETTING: Patients from a single-institution tertiary care center were studied. PATIENTS: A total of 224 patients with colorectal cancer under 40 years of age diagnosed between 1990 and 2010 were included (mean age, 34.7 years; 51.3% female). 34 patients (15.2%) had mucinous histology. INTERVENTIONS(S): There were no interventions. MAIN OUTCOME MEASURES: Oncologic outcomes were analyzed according to the presence of mucinous histology. RESULTS: The mucinous and nonmucin colorectal cancer study populations were statistically similar in age, sex, tumor location, pathological stage, differentiation, and adjuvant chemotherapy use. Five-year disease-free survival was 29.1% versus 71.3% (p

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