Association of Neuronal Injury in the Genu and Body of Corpus Callosum Following Cranial Irradiation in Children with Impaired Cognitive Control: A Prospective Study

The purpose of this prospective study was to examine white matter integrity as measured by DTI and the association with region specific radiation therapy dose and neuropsychological functioning in children treated with cranial irradiation. These data suggest that subcortical white matter, especially the genu and body of the corpus callosum, may be regions with increased susceptibility to radiation-induced injury with implications for cognitive function.

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