Nanoscaled Metal-Organic Frameworks for Biosensing, Imaging, and Cancer Therapy

Abstract

Owing to the progressive development of metal-organic frameworks (MOFs) synthetic processes and their unique characters associated with the excellent performance-selectable composition, tunable pore scale, large surface area, and good thermal stability, MOFs have captured the interest and the imagination of an increasing number of scientists working in different fields. In the area of biomedical applications, MOFs are especially involved in sensing, molecular imaging, and drug delivery, with strong contributions to the whole nanomedicine area. Recently, these materials have been scaled down to nanometer sizes with the advancement of chemical synthesis gradually reaching an adjustable level. This review mainly discusses and summarizes the general synthesis, properties, and biomedical applications of nanoscaled MOFs and their composites in biosensing, imaging, and cancer therapy within the latest three years. The remaining challenges and future opportunities in this field, in terms of processing techniques, maximizing composite properties, and prospects for clinical applications, are also indicated.

The recent progress in the development of nanoscaled metal-organic frameworks for biomedical application is reviewed via a broad perspective. Typical examples in biosensing, molecular imaging, cancer treatment, and cancer theranostics are discussed. The remaining problems and promising breakthroughs in this field are also outlined.

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