Intratumoral and Peritumoral Lymphovascular Invasion Detected by D2–40 Immunohistochemistry Correlates with Metastasis in Primary Cutaneous Merkel Cell Carcinoma

Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2–40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2–40 IHC compares with LVI detected by hematoxylin–eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated during 2002–2015 were assembled and included 58 MCC tumors from 58 patients.

https://ift.tt/2GBBDGm