Incomplete systematic meta-analysis of pharmacological therapies for opioid induced constipation

Re: Drugs for treating opioid-induced constipation: A mixed treatment comparison network meta-analysis of randomized controlled clinical trials. J Pain Symptom Manage 2018 Feb;55:468-479.e1. doi: 10.1016/j.jpainsymman.2017.08.022.Epub 2017 Sep 15. One question came in mind was the completeness of systematic review reported by Sridharan et al.1) While our publication on naldemedine 2) (reference 40) was included in the analysis, at least two other key papers on naldemedine published before the cutoff date were missed (Webster et al3), Pain Med.

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