Strong Androgen Receptor Expression Can Aid in Distinguishing GATA3+ Metastases

GATA3 is a transcription factor used clinically as a marker of breast or urothelial differentiation. A marker is yet needed to distinguish these in the case of the GATA3 positive tumor of unknown origin. We tested classical markers of breast differentiation and hormonal signaling to see which correlated strongest with GATA3 expression in breast cancer and thus which could help correctly identify breast origin in the case of the GATA3 positive tumor of unknown origin. GATA3, estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), HER2, GCDFP15, and mammaglobin expression was inter-correlated in a histologically diverse 259 case breast cancer tissue microarray.

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