Improved overall survival of mice by reducing lung side effects after high precision heart irradiation using SARRP

In radiotherapy of thoracal tumors parts of the heart and lung are often included in the radiation field. As a consequence, patients harbor an increased risk of developing radiation induced heart (RIHD) and lung diseases (RILD). There is clinical evidence that RIHD and RILD synergistically increase morbidity. This problem has also been observed in preclinical studies on RIHD in mice. The aim of this study was to reduce radiation exposure of the lung in experimental models to increase overall survival of mice to study late RIHD.

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