Gastric mucosal devitalization is safe and effective in reducing body weight and visceral adiposity in a porcine model

The early improvement in metabolic profile after sleeve gastrectomy (SG) indicates that the significant benefits of metabolic surgery are gastric in origin. We have previously demonstrated that devitalization of the gastric mucosa (without a reduction in gastric volume) in metabolically disturbed obese rats results in an improvement of obesity and its associated comorbidities. The aims of this study were to assess the technical feasibility, efficacy and safety of gastric mucosal devitalization (GMD) in a large animal (porcine) model.

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