Short diffusion time DWI with oscillating gradient preparation as an early MRI biomarker for radiation therapy response monitoring in glioblastoma: A pre-clinical feasibility study

This study investigates DWI at very short diffusion times (Δeff) as a novel tool for radiotherapy monitoring and response detection in a glioblastoma mouse model. Using oscillating gradient diffusion MRI (OGSE) to overcome Δeff limits in conventional DWI we show that ADC mapping at short Δeff can detect radiation changes significantly earlier and more robustly than standard clinical DWI. We believe that short Δeff DWI is highly promising for radiotherapy monitoring on a cellular level.

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