Is focal active colitis of greater clinical significance in pediatric patients? A retrospective review of 68 cases with clinical correlation

Focal active colitis (FAC) is a histopathologic finding of uncertain clinical significance in individual patients. In adults, infection accounts for approximately 50%, Crohn's disease (CD) for 0–13%, and 20–30% are idiopathic. One previous study of 29 cases of pediatric FAC showed a 28% rate of CD. This study reviewed a larger cohort of pediatric patients to determine what proportion had IBD, and whether an amount or pattern of inflammation could predict IBD. Sixty eight patients aged ≤18years with FAC were identified and reviewed.

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