2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma

Abstract

With the ever-deeper understanding of nano–bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process. Additionally, a corrugated structure analogous to Haversian canals is found on newborn cranial bone tissue of Sprague–Dawley rats, which may provide much inspiration for the future research of bone-tissue engineering.

A stepwise nanomedical therapeutic concept is proposed for osteosarcoma therapy by integrating 2D black phosphorous nanosheets into 3D-printed bioglass scaffolds, which are capable of accomplishing combined photothermal therapy of tumors with the formation of new osseous tissue accompanying the degradation of the scaffolds, as systematically demonstrated both in vitro and in vivo.

http://ift.tt/2mz5pzj