Proton pump inhibitors and gastric cancer: a long expected side effect finally reported also in man

We read with interest the report by Cheung et al describing increased risk of gastric cancer in patients treated long-term proton pump inhibitor (PPI) after Helicobacter pylori eradication.1 On the same day, a Swedish study also reported increased risk of gastric cancer in patients having been treated long-term with PPI.2 Since cancers in general most often require decades to develop, the magnitude of the PPI-related cancer risk cannot be foreseen. For 30 years, we have worked with the role of gastrin and the risk of PPI treatment with respect to gastric cancer and published more than 200 papers and letters in this field. However, our publications have for one reason or the other been overseen and not discussed. On the other hand, since we always have concluded that PPI treatment in the long term would cause gastric cancer, it is strange that producers of PPIs have not done studies...

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