How Valid Are GFR Estimation Results From the CKD-EPI Databases?

Levey et al1 concluded that current evidence does not support reporting estimated glomerular filtration rate using any other creatinine equation than CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). However, their results do not provide evidence of external validity; the original authors of the equation,2 after analyzing multiple models in the CKD-EPI database (n=3,896), stated "We selected a single model as the best equation for general use."2(p 605) A true external validation should not influence the equation coefficients or which equation is finally selected.

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