Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Have Metastatic Potential

Abstract

We read with great interest the study by Li et al. entitled "Re-evaluation of 33 "Unclassified" Eosinophilic Renal Cell Carcinomas in Young Patients", in which the authors describe the significant degree of histologic overlap between different subtypes of renal cell carcinomas (RCCs) with eosinophilic/oncocytic features occurring in young patients. This study highlights the fact that the prototypical pathologic features, particularly for FH-deficient and SDH-deficient RCCs, are often not as well-developed in younger patients, a finding also recently described by Smith et al. Li et al. also report 10 new cases of the recently described eosinophilic solid and cystic (ESC) RCC in young patients, one of which was associated with liver and lung metastases.

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