Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity

Anti-inflammatory PI3K-Akt signaling is suppressed in patients with cystic fibrosis (CF), a disease characterized by hyper-inflammatory responses to airway infection. Riquelme et al. find that CFTR channel directly interacts with tumor suppressor PTEN, which regulates PI3K activity. CFTR helps position PTEN at the membrane to promote PTEN function and host immunity against Pseudomonas aeruginosa infection.

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