Characterization of KPC-encoding plasmids from Enterobacteriaceae isolated in a Czech hospital [PublishAheadOfPrint]

Ten Enterobacteriaceae, collected in a Czech hospital, carried bla_KPC-positive plasmids of different sizes (~30, ~45, and ~80 kb). Sequencing revealed three types of plasmids (A to C) with Tn4401a. Type A plasmids comprised an IncR backbone and a KPC-2-encoding multidrug resistant (MDR) region. Type B were derivatives of type A plasmids carrying an IncN3-like segment, while type C were IncP6 plasmids sharing the same KPC-2-encoding MDR region with type A and B plasmids.

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