Adaptive boost target definition in high-risk head and neck cancer based on multi-imaging risk biomarkers

Several imaging risk biomarkers for treatment failure in head and neck cancer have been identified, largely in isolation. Understanding the spatial association between these imaging risk biomarkers is lacking, which could impact on decision making in clinical trials. This study found that high FDG uptake, low blood volume and low diffusion coefficient in head-and neck cancer identifies large distinct tumor subvolumes. Boosting target defined on a single imaging modality may not be adequate to achieve sufficient clinical benefits.

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