Adalimumab in Crohn's strictures--the CREOLE study

We compliment the authors of the CREOLE study1 evaluating the efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture. That about two-thirds of patients responded at 24 weeks and about a third of the symptomatic patients were able to avoid surgery at 4 years is impressive. The authors also need to be complimented for attempting to develop a predictive model.

A typographical error seems to have unfortunately crept into their manuscript. Table 3 mentions the length of the strictures on MRI in millimetres, when they probably meant centimetres.

Three of the ninety-seven patients in this study had L2 disease; the inclusion criteria were restricted to patients with small bowel strictures. Did these patients have colonic strictures as well? Would the symptoms then not be misleading?

Crohn's disease obstructive score is a tool based on the experience of the authors and needs validation. It is subjective and...

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