Zeroing in on endoscopic and histologic mucosal healing to reduce the risk of colorectal neoplasia in inflammatory bowel disease

The past 2 decades have witnessed unprecedented advances in our understanding of the causes and pathogenesis of inflammatory bowel disease (IBD). Taken together with an expanding therapeutic armamentarium, this has emboldened the definitions of disease control, placing greater emphasis on achieving mucosal healing than on clinical remission alone. What can now be achieved through abrogation of immunoinflammatory events such as reduction in disease relapse, hospitalization, surgery, and colorectal neoplasia (CRN) has redefined our perceptions of meaningful disease control.

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