Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies

Abstract

Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to date has been preclinical. However, examples of approved treatments particularly in vaccines, dentistry, and hemostasis demonstrate the translational potential of supramolecular polypeptides. Critical milestones in the clinical development of this class of materials and currently approved supramolecular polypeptide therapies are described in this study. Additional examples of not-yet-approved materials that are steadily advancing toward clinical use are also featured. Spherical assemblies such as virus-like particles, designed protein nanoparticles, and spherical peptide amphiphiles are highlighted, followed by fiber-forming systems such as fibrillizing peptides, fiber-forming peptide-amphiphiles, and filamentous bacteriophages.

Supramolecular peptide biomaterials are being advanced toward clinical applications. This progress report describes self-assembled polypeptide biomaterials that have been translated into clinical applications, along with those making steady progress toward patients. Although the majority of new supramolecular polypeptide materials have yet to be translated, the regulatory approval and commercialization of several examples is encouraging for the field.

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