How to Make Pediatric Trials Better: Transparency and Accountability of Trial Registration and Reporting

In this volume of The Journal, Gates at al showed the changing landscape of pediatric clinical trials, with important shifts in study designs, outcome reporting, and risk of bias analysis.1 Compared with 2007, pediatric trials in 2012 were more complex and significantly more often specified the primary outcome and reported funding and trial oversight by a data monitoring committee. However, it is very troubling that only 38% of trials in the 2012 sample of trials specified a primary outcome, and that one-half of them had high bias or unclear reporting surrounding the blinding schemes and research staff involved in the allocation.

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