Combination immune-based therapy for chronic ITP

Idiopathic thrombocytopenia purpura (ITP) is a common pediatric disorder that often dramatically presents with sudden onset bruising, petechiae, and (typically quite severe) thrombocytopenia. While various therapies (glucocorticoids, intravenous gamma globulin, intravenous anti-D) can transiently increase the platelet count, serious bleeding from acute ITP is uncommon, with little evidence that preemptive treatment reduces either the risk of serious bleeding or the already low (10-15%) incidence of developing chronic ITP.

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