This schematic image portrays phosphoinositide interconversions coordinated by complexes of phosphoinositide kinases and phosphatases (lower membrane), as discussed in article 1700121 by Choy et al. Effector recruitments by co-incident detection (upper membrane) and various phosphoinositide-binding effector proteins (Akt, PDK1, Tubby, Tup1, Cti6, EEA1) (in the cytosol) are depicted. In the middle is shown the nucleus that contains inositol polyphosphates, secondary metabolites derived from phosphoinositides.
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