18F-FAZA PET/CT Hypoxia Imaging of High-Grade Glioma Before and After Radiotherapy

Abstract: A 57 year-old man underwent MRI with dynamic susceptibility contrast and dynamic contrast-enhanced perfusion for neurological symptoms suggesting the diagnosis of high-grade glioma. A 18F-FAZA PET/CT was performed because of the enrollment in a prospective clinical trial. Subsequent radiotherapy treatment has been planned based on conventional imaging; moreover, a 18F-FAZA PET/CT–guided treatment planning highlighting hypoxic regions has been simulated. After radiotherapy treatment, the man underwent MRI and 18F-FAZA PET/CT, showing partial response.

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