Response:

We would like to thank Drs Buxbaum and Yu1 for their contributions to the literature on preventing post-ERCP pancreatitis (PEP) and for their thoughtful assessment of our study.2 Although we agree with the authors' pharmacodynamic assessment of lactated Ringer's solution (LR) in preventing PEP, we believe that it is important to point out several things regarding the timing of volume resuscitation and of other interventions used to prevent PEP.

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