Photothermal Therapy: 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy (Adv. Mater. 40/2017)

One-dimensional nanoscale coordination polymers (1D NCPs) are fabricated by Lai Xu, Meiwan Chen, Zhuang Liu, and co-workers by simply mixing metal ions and the organic ligand indocyanine green together with polyhistidine–poly(ethylene-glycol) copolymer, and then further loading with gambogic acid, as described in article number 1703588. Such 1D NCPs with efficient pH-responsive tumor retention enables effective destruction of tumors under low-temperature photothermal heating, owing to the gambogic-acid-induced down-regulation of heat-shock protein 90 to overcome the thermal-resistance of tumor cells.

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