PET-Adjusted Intensity-Modulated Radiotherapy for Locally Advanced Non-small Cell Lung Cancer

We performed a prospective trial using dose-painted IMRT based on pre-treatment PET metrics with concurrent chemotherapy for locally advanced NSCLC. We found that this approach yields high rates of metabolic response on post-treatment PET. Use of a relatively low dose for low-risk tumors and lymph nodes does not seem to compromise local control of those lesions. This approach should be pursued to maximize the therapeutic ratio of radiotherapy in this setting.

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