Neoadjuvant Chemoradiation in the Treatment of Locally Advanced Breast Cancer

Despite the clear benefit of neoadjuvant chemoradiation in multiple disease sites, including head and neck, lung, and gastrointestinal malignancies, its role in breast cancer remains unclear. In this issue of the International Journal of Radiation Oncology • Biology • Physics, 2 phase 2 trials examine the role of neoadjuvant chemoradiation in the treatment of patients with breast cancer. These 2 studies examine different treatment regimens and use very different eligibility criteria and different endpoints, making meaningful comparison between them difficult.

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