Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

The mechanisms driving human germ cell specification are largely unknown. Kojima et al. define the signaling and transcriptional programs that drive human germ cell specification in vitro, which show substantial evolutionary divergence from mouse programs. These findings serve as a foundation for further reconstitution of human germ cell development.

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