Analysis of Claims that the Brain Extracellular Impedance Is High and Non-resistive

Numerous measurements in the brain of the impedance between two extracellular electrodes have shown that it is approximately resistive in the range of biological interest, <10 kHz, and has a value close to that expected from the conductivity of physiological saline and the extracellular volume fraction in brain tissue. Recent work from Gomes et al. has claimed that the impedance of the extracellular space is some three orders of magnitude greater than these values and also displays a frequency dependence (above a low-frequency corner frequency).

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