Acute Kidney Injury, Hypercalcemia, and Osteolytic Lesions: A Familiar Triad With a Rare Cause Complicated by Posterior Reversible Encephalopathy Syndrome

A 64-year-old Chinese man with a history of well-controlled hypertension presented with a 3-week history of central and right-sided chest pain that he had been treating with nonsteroidal anti-inflammatory drugs. He had acute kidney injury (AKI), with serum creatinine concentration of 3.65mg/dL (from a baseline value of 1.1mg/dL) and severe hypercalcemia (corrected calcium, 3.8mmol/L) with suppressed parathyroid hormone (PTH) concentration (Table 1). He had radiologic evidence of rib fractures along with innumerable lytic lesions in his skull, appendicular, and axial skeleton (Fig 1A-C).

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