Two cases of benign fibrous histiocytomas (dermatofibromas) associated with Langerhans cell histiocytosis

Abstract

We report two cases of fibrous histiocytoma (FH) associated with discrete nodular aggregates of Langerhans cells (LCs) resembling Langerhans cell histiocytosis (LCH). In addition, the LCs showed positivity for BRAF V600E immunohistochemistry, a finding reported in neoplastic but not reactive LCs ¹. To our knowledge, these cases represent the first published association of FH and LCH.

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