Ki-67 labeling index may be a promising indicator to identify “very high risk” gastrointestinal stromal tumor (GIST): a multicenter retrospective study of 1022 patients

We sought to determine whether Ki-67 labeling index (LI) was an independent prognostic factor for gastrointestinal stromal tumor (GIST). A multicenter cohort of 1022 patients undergoing surgical resection of primary GIST between August 2004 and October 2015 were retrospectively analyzed. Immunohistochemical analysis was performed to evaluate expression of Ki-67 in their parafin-embedded tissue samples. The optimal cutoff value of Ki-67 LI was determined as 6% by receiver operating characteristics (ROC) curve analysis.

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