Identification of ATIC as a novel target for chemoradiosensitization

Detection of a frameshift mutation in the gene encoding the purine biosynthetic enzyme ATIC in a panel of radiosensitive individuals prompted studies to elucidate the role of ATIC in DNA damage responses and ascertain whether inhibition of ATIC might be an effective chemoradiosensitization strategy. Knockdown of ATIC or inhibition of its enzymatic activity compromised DNA double strand break repair and reduced cell survival after irradiation.

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