S199 Generation of healthy and pathological synchronous events in the hippocampus: Modulation of cellular and network parameters results in altered dynamics

Cortical activity is characterized by behavior associated alternation of network states, such as physiological sharp-wave ripples (SWRs) and theta phase modulated gamma in the hippocampus. Epileptiform bursts are characteristic in the pathological case. In in vitro mouse hippocampal slice preparation the activity can be switched among SWR, gamma and epileptic states.We asked:SWRs and epileptiform bursts share similar initiation mechanisms, and express high-frequency oscillations (HFOs) with different features.

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